I'd think that just aiming at the West Hills and then taking the Zoo path:
up and over would be your best bet. The only problem will be the first couple miles after you leave work. Use low gears!
FWIW: I'm coming in from the opposite direction. I live in east Vancouver and work at Emanuel as a pharmacy tech. It's pretty flat until I get close to home- then it's a short 7-8% climb. Ugh.